Inhibition of coding region determinant binding protein sensitizes melanoma cells to chemotherapeutic agents
نویسندگان
چکیده
منابع مشابه
PUMA sensitizes lung cancer cells to chemotherapeutic agents and irradiation.
PURPOSE Lung cancer, the leading cause of cancer mortality worldwide, is often diagnosed at late stages and responds poorly to conventional therapies, including chemotherapy and irradiation. A great majority of lung tumors are defective in the p53 pathway, which plays an important role in regulating apoptotic response to anticancer agents. PUMA was recently identified as an essential mediator o...
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Uncoupling protein-2 (UCP2) is known to suppress mitochondrial reactive oxygen species (ROS) production and is employed by drug-resistant cancer cells to mitigate oxidative stress. Using the drug-sensitive HL-60 cells and the drug-resistant MX2 subline as model systems, we show that genipin, a UCP2 inhibitor, sensitizes drug-resistant cells to cytotoxic agents. Increased MX2 cell death was obse...
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BACKGROUND AND OBJECTIVES Management of patients with breast cancer often fails because of inherent or acquired resistance to chemotherapy. BRUCE (BIR repeat containing ubiquitin-conjugating enzyme) is a member of the inhibitor of apoptosis protein (IAP) family. It has various cellular functions including suppression of apoptosis and promotion of cytokinesis. Furthermore, it pays a critical rol...
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ژورنال
عنوان ژورنال: Pigment Cell & Melanoma Research
سال: 2011
ISSN: 1755-1471
DOI: 10.1111/j.1755-148x.2011.00921.x